ما هو تأثير الanion بالproximal tubule على الuric acid وامتصاصه؟

renal excretion of urate appears to be dependent on the balance between filtration, secretion, and reabsorption, with the latter two processes (though acting in opposition) occurring in overlapping segments of the proximal tubule of the kidney and, indeed, potentially in the same proximal tubular cell Recent studies suggest that the reabsorptive component of this overall process is principally mediated by urate transporter 1 (URAT1)which manifests functional properties consistent with those of proximal tubular urate reabsorption, including anion exchange and inhibition by uricosuric agents